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Lacrimal Gland Degeneration

Tear Production Decline and Ocular Surface Disease

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Göz Hastalıkları department. Book Appointment →

What is Lacrimal Gland Degeneration?

The lacrimal gland produces the aqueous component of tears that lubricates and nourishes the ocular surface

Degeneration involves acinar atrophy, fibrosis, and loss of secretory cells over time

The condition is a leading cause of aqueous-deficient dry eye disease, particularly in older adults

Histopathology reveals lymphocytic infiltration, ductal dilation, and parenchymal replacement by fat

Both age-related and autoimmune (Sjögren) forms exist with overlapping features

Symptoms

Persistent dryness, grittiness, and foreign body sensation in the eyes
Burning, stinging, and photophobia worsening throughout the day
Blurred or fluctuating vision relieved by blinking
Mucous discharge and tired heavy eyelids
Reflex tearing in cold or windy conditions despite chronic dryness

Risk Factors

Advanced age (over 60 years) with natural lacrimal involution
Female sex with postmenopausal hormonal changes
Sjögren syndrome and other systemic autoimmune diseases
Long-term contact lens wear and refractive surgery history
Medications such as antihistamines, antidepressants, and beta-blockers

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Daily symptoms persisting for more than 3 months despite artificial tears
  • Visual blurring affecting reading or driving safety
  • Severe pain, redness, or light sensitivity suggesting corneal involvement
  • Suspected Sjögren syndrome with dry mouth and joint symptoms
  • Failure of over-the-counter lubricants to provide relief

Treatment Methods

01
Preservative-free artificial tears, gels, and ointments tailored to severity
02
Topical anti-inflammatory drops (cyclosporine, lifitegrast, corticosteroids)
03
Punctal plugs to retain natural tears on the ocular surface
04
Autologous serum tears, scleral lenses, and amniotic membrane for severe cases
05
Treatment of underlying systemic disease and review of contributing medications

Which Department to Visit?

You can visit our Göz Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Göz Hastalıkları Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.