Interstitial Nephritis

Inflammation of the renal interstitium and tubules.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 11, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Interstitial Nephritis?

Acute interstitial nephritis presents with sudden renal dysfunction, fever, rash and eosinophilia and is typically triggered by NSAIDs, antibiotics, proton pump inhibitors and immune checkpoint inhibitors.

Chronic interstitial nephritis develops slowly, leading to fibrosis, tubular atrophy and progressive loss of glomerular filtration; analgesic abuse, heavy metals and obstruction are common causes.

Diagnosis is based on history of drug use, urinalysis findings such as sterile pyuria and white-cell casts, eosinophiluria, imaging and definitive kidney biopsy.

Symptoms

Reduced urine output

Fever

Skin rash

Flank pain

Fatigue

Joint pain

Eosinophilia

Risk Factors

Long-term NSAID use

Recent antibiotic use

Proton pump inhibitor therapy

Immune checkpoint inhibitor therapy

Autoimmune disease

Recurrent urinary tract infection

Heavy metal exposure

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Sudden decline in urine output
Fever and rash with new drug
Persistent flank pain
Foamy urine
Symptoms of uraemia

Treatment Methods

Discontinuation of the offending drug

Treatment of underlying infection

Short-course corticosteroids in selected cases

Hydration and electrolyte management

Dialysis in severe acute kidney injury

Long-term nephrology follow-up

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.