The information on this website is not intended for diagnosis or treatment. Please consult your physician for health concerns.

+90 850 321 50 00

Immune Deficiency Screening in Hematology

Primary and secondary immunodeficiency evaluation in recurrent infections

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Hematoloji department. Book Appointment →

What is Immune Deficiency Screening in Hematology?

Immune deficiency screening is a systematic evaluation of immune system components in patients presenting with recurrent unusual or severe infections. Screening includes quantitative immunoglobulin levels lymphocyte subsets neutrophil function and complement assays. The goal is identifying primary congenital or secondary acquired immunodeficiency.

Common indications include more than two pneumonias yearly recurrent sinopulmonary infections opportunistic infections failure to thrive autoimmune cytopenias and family history of immunodeficiency. Initial workup measures complete blood count differential immunoglobulin G A M E and isohemagglutinin titers along with vaccine response.

Specialized testing includes lymphocyte enumeration by flow cytometry mitogen response complement CH50 and AH50 neutrophil oxidative burst by dihydrorhodamine and genetic panels for suspected primary immunodeficiency. Referral to clinical immunology is recommended for confirmed or suspected disorders requiring specific therapy.

Symptoms

Recurrent bacterial respiratory infections
Opportunistic or unusual pathogen infections
Failure to thrive in pediatric patients
Chronic diarrhea or malabsorption
Autoimmune cytopenias or lymphoproliferation

Risk Factors

Family history of immunodeficiency
Consanguineous parental relationships
Long term immunosuppressive therapy
Hematologic malignancy or HIV infection
Chemotherapy or radiotherapy exposure

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When recurrent infections exceed expected frequency
  • When opportunistic infections occur in adults
  • When chronic infections fail standard therapy
  • When family history suggests primary immunodeficiency

Treatment Methods

01
Quantitative immunoglobulin measurement initially
02
Vaccine response and isohemagglutinin titers
03
Lymphocyte subset enumeration by flow cytometry
04
Neutrophil oxidative burst when phagocytic defect suspected
05
Genetic testing for suspected primary immunodeficiency
06
Clinical immunology referral for confirmed cases

Which Department to Visit?

You can visit our Hematoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Hematoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

Book AppointmentContact Us

Related Health Topics

Other articles from the same department you may want to explore.

Anaemia

Dahiliye (İç Hastalıkları)

Anaemia is a low haemoglobin level that reduces oxygen delivery, causing fatigue, pallor, and shortness of breath. It is not a disease itself but a sign of many underlying conditions. Most cases are correctable with appropriate diagnosis and treatment.

Iron Deficiency Anaemia

Dahiliye (İç Hastalıkları)

Iron deficiency anaemia develops when dietary intake, absorption, or losses create an iron shortfall, most often affecting women and children. Identifying the underlying cause is the core of management, alongside iron replacement.

Vitamin B12 Deficiency

Dahiliye (İç Hastalıkları)

Vitamin B12 deficiency can cause megaloblastic anaemia, neurological symptoms, and cognitive impairment. Early treatment with intramuscular or oral B12 largely prevents irreversible complications.

Hypertension (High Blood Pressure) Management

Dahiliye (İç Hastalıkları)

Hypertension is often called the silent killer because it progresses symptom-free for years and can damage the heart, brain, kidneys, and eyes. Regular monitoring, lifestyle change, and evidence-based drug therapy dramatically reduce cardiovascular risk.

Chronic Kidney Disease

Dahiliye (İç Hastalıkları)

Chronic kidney disease is one of the most common complications of chronic conditions such as diabetes and hypertension, and can be silent in its early stages.

Hepatitis B (HBV)

Dahiliye (İç Hastalıkları)

Hepatitis B is a DNA virus infection causing acute and chronic hepatitis with risk of cirrhosis and hepatocellular carcinoma; diagnosis integrates HBsAg, HBeAg, anti-HBc, and HBV DNA with management based on disease phase using nucleos(t)ide analogues (entecavir, tenofovir) and universal infant vaccination.

Hepatitis C (HCV)

Dahiliye (İç Hastalıkları)

Hepatitis C is an RNA virus causing chronic hepatitis that may progress to cirrhosis and hepatocellular carcinoma; modern direct-acting antiviral (DAA) pangenotypic regimens (sofosbuvir/velpatasvir, glecaprevir/pibrentasvir) achieve sustained virologic response over 95% in 8–12 weeks with universal adult screening and cure for nearly all patients.

Fatty Liver Disease

Dahiliye (İç Hastalıkları)

Non-alcoholic fatty liver disease (NAFLD) is closely related to obesity and metabolic syndrome and is largely reversible with early treatment.

Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.