Hypercalciuric Nephrolithiasis

The most common metabolic subtype of kidney stone disease.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 9, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Hypercalciuric Nephrolithiasis?

A significant proportion of patients with calcium stones have increased 24-hour urinary calcium excretion (>250 mg/day in women, >300 mg/day in men). This entity is known as hypercalciuric nephrolithiasis.

Causes include idiopathic absorptive hypercalciuria, renal hypercalciuria, vitamin D excess, hyperparathyroidism, sarcoidosis, immobilization, and high salt intake.

Lifestyle modifications, high fluid intake, salt restriction, animal protein reduction, and thiazide diuretics are the cornerstones of treatment. They reduce recurrent stone formation.

Symptoms

Recurrent kidney stones

Colicky flank pain

Hematuria

Urinary tract infection

Stone passage

Family history of urolithiasis

Heavy urinary sediment

Risk Factors

High salt intake

Excessive animal protein consumption

Low fluid intake

Familial hypercalciuria

Primary hyperparathyroidism

Vitamin D toxicity

Sarcoidosis and granulomatous disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Recurrent stone passage
Hematuria and flank pain
Bilateral stones
Stone disease at a young age
Family history of urolithiasis
Hypercalciuria on 24-hour urine

Treatment Methods

Daily fluid intake of 2.5-3 L

Salt restriction (<5 g/day)

Animal protein reduction

Thiazide diuretic (hydrochlorothiazide)

Citrate supplementation

Treatment of the underlying cause

24-hour urine monitoring

Joint follow-up by urology and nephrology

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.