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Hepatitis D (Delta) Superinfection

Virus that adds onto chronic HBV and causes severe hepatitis.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Internal Medicine department. Book Appointment →

What is Hepatitis D (Delta) Superinfection?

The hepatitis D virus (HDV) is a defective RNA virus that requires HBsAg for replication. For this reason it can only coexist with HBV.

Addition of HDV to a chronic HBV carrier (superinfection) leads to a much more severe clinical picture, rapid liver damage, early development of cirrhosis, and increased risk of hepatocellular carcinoma.

Diagnosis is made with anti-HDV and HDV RNA testing; treatment includes pegylated interferon and the newer agent bulevirtide.

Symptoms

Sudden deterioration in a patient with chronic HBV
Marked jaundice
Abdominal pain
Nausea and loss of appetite
Encephalopathy (in severe cases)
Rapidly progressing signs of cirrhosis
Severe fatigue

Risk Factors

Chronic HBV infection
Living in HBV-endemic areas
Intravenous drug use
Multiple sexual partners
HIV co-infection
Hemodialysis
Migration from HDV-endemic regions

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Sudden ALT elevation in a chronic HBV patient
  • Clinical worsening and increasing jaundice
  • Screening of migrants from HDV-endemic areas
  • Signs of liver failure
  • As part of HCC screening

Treatment Methods

01
Pegylated interferon alfa
02
Bulevirtide (new therapy)
03
Entecavir or tenofovir for HBV
04
Close clinical and laboratory follow-up
05
Management of cirrhosis complications
06
Transplantation evaluation (in severe cases)

Which Department to Visit?

You can visit our Enfeksiyon Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Enfeksiyon Hastalıkları Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.