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Hypercoagulability Screening in Hematology

Selective thrombophilia testing in venous thromboembolism evaluation

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Hematoloji department. Book Appointment →

What is Hypercoagulability Screening in Hematology?

Hypercoagulability screening evaluates inherited and acquired thrombophilia in patients with venous thromboembolism. Inherited disorders include factor five Leiden, prothrombin G twenty two ten one zero A mutation, antithrombin deficiency, protein C deficiency, and protein S deficiency. Acquired states include antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, and malignancy associated thrombosis.

Indications for testing focus on unprovoked thromboembolism in young patients, recurrent events, family history, unusual sites such as portal or cerebral veins, and pregnancy loss. Routine testing in elderly patients with strong provoking factors offers little incremental value because anticoagulation duration is already determined.

Timing matters. Antithrombin levels fall during acute thrombosis, protein C and S levels fall on warfarin, and direct oral anticoagulants interfere with lupus anticoagulant testing. Repeat confirmation after at least three months of anticoagulation is recommended for abnormal results.

Symptoms

Unprovoked deep venous thrombosis
Pulmonary embolism without major risk factors
Cerebral or splanchnic vein thrombosis
Recurrent pregnancy loss
Family history of early thrombosis

Risk Factors

First degree relative with thrombosis
Recurrent thrombotic events
Thrombosis in unusual sites
Recurrent pregnancy loss
Coexisting autoimmune disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When unprovoked thromboembolism occurs in youth
  • When events recur on or off anticoagulation
  • When pregnancy loss is recurrent
  • When unusual site thrombosis is identified
  • When family screening is considered

Treatment Methods

01
Selective thrombophilia testing in indicated patients
02
Lupus anticoagulant and antiphospholipid antibody panel
03
Factor five Leiden and prothrombin gene tests
04
Antithrombin protein C and protein S activity
05
Repeat confirmation after acute event and warfarin
06
Anticoagulation choice and duration based on clinical context
07
Family screening and counseling for hereditary disorders

Which Department to Visit?

You can visit our Hematoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.