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ESBL-Producing Bacterial Infections

Resistant infections caused by gram-negative bacteria producing extended-spectrum beta-lactamases

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Internal Medicine department. Book Appointment →

What is ESBL-Producing Bacterial Infections?

Extended-spectrum beta-lactamases (ESBLs) are enzymes that hydrolyze penicillins and third-generation cephalosporins. They are most commonly seen in E. coli and Klebsiella pneumoniae strains.

ESBL producers are increasingly identified in community-acquired urinary tract infections as well; rectogenital colonization plays a role in transmission and recurrence.

Early diagnosis and appropriate antibiotic selection reduce complications, length of stay, and mortality.

Symptoms

Recurrent urinary tract infection
Fever and flank pain
Signs of systemic infection
Bacteremia and sepsis
Lack of clinical response to therapy

Risk Factors

Broad-spectrum antibiotic use
Recent hospitalization
Urinary catheter
Older age and diabetes
Travel history (high-prevalence regions)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When a UTI is unresponsive to standard antibiotics
  • When sepsis develops
  • With a history of recurrent pyelonephritis
  • In febrile UTI in older or immunosuppressed patients

Treatment Methods

01
Carbapenems (ertapenem, meropenem)
02
Piperacillin-tazobactam (in mild cases)
03
Ceftazidime-avibactam (selected cases)
04
Oral fosfomycin or nitrofurantoin (uncomplicated cystitis)
05
Antibiotic stewardship
06
Infection control for colonization

Which Department to Visit?

You can visit our Enfeksiyon Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Enfeksiyon Hastalıkları Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.