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Erythema Nodosum

A septal panniculitis presenting as painful, red subcutaneous nodules on the legs.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Erythema Nodosum?

Erythema nodosum is an immune-mediated inflammation of the subcutaneous fat tissue (septal panniculitis). It presents as symmetrical, tender, red-purple nodules on the anterior surface of the legs.

Triggers include streptococcal infections, tuberculosis, sarcoidosis, inflammatory bowel disease, Behçet disease, certain medications, and pregnancy. In about half of cases the cause cannot be identified (idiopathic).

Lesions resolve within 3-6 weeks without scarring; a 'bruise-like' appearance with color change is typical. Investigation of an underlying disease is essential.

Symptoms

Painful, warm nodules on the front of the legs
Symmetrical distribution of lesions
Nodules that take on a purple-yellow 'bruise-like' appearance over time
Fever and malaise
Joint pain and swelling
Edema of the legs
No ulceration or scarring

Risk Factors

Recent streptococcal throat infection
Tuberculosis or other granulomatous infections
Sarcoidosis
Inflammatory bowel disease
Behçet disease and other vasculitides
Drugs such as oral contraceptives, sulfonamides
Pregnancy and young female sex

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When painful, red nodules appear on the legs
  • If accompanied by fever, weight loss, and night sweats
  • If joint pain, abdominal pain, or diarrhea is present
  • When nodules ulcerate
  • When an underlying systemic disease is suspected

Treatment Methods

01
Treatment of the underlying cause
02
Rest and leg elevation
03
NSAIDs to reduce pain and inflammation
04
Potassium iodide (in selected cases)
05
Systemic corticosteroids in resistant cases
06
Compression bandaging and follow-up

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.