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Eosinophilic Gastroenteritis (Detailed)

A rare disease characterised by eosinophil infiltration of the gastrointestinal tract.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Eosinophilic Gastroenteritis (Detailed)?

Eosinophilic gastroenteritis is a rare disease characterised by significant eosinophil infiltration of one or more layers of the wall of the stomach and small intestine. According to the Klein classification it is divided into three forms: mucosal, muscular and serosal, and the clinical picture varies depending on the layer involved.

The mucosal form is the most common and presents with diarrhoea, abdominal pain, malabsorption and protein-losing enteropathy. Obstructive symptoms predominate in the muscular form, while eosinophilic ascites is the prominent feature of the serosal form. Approximately 50-70% of patients have a history of atopy.

Diagnosis requires peripheral eosinophilia, more than 20 eosinophils/high-power field in endoscopic biopsy and exclusion of other causes of eosinophilia (parasites, drugs, vasculitis, lymphoma). Dietary elimination and corticosteroids are essential in treatment.

Symptoms

Abdominal pain and cramps
Nausea and vomiting
Chronic diarrhoea
Weight loss and malabsorption
Obstructive symptoms (muscular form)
Ascites (serosal form)
Food allergies and atopy
Anaemia and hypoalbuminaemia

Risk Factors

Atopic diseases (asthma, allergic rhinitis, eczema)
Food allergies
Family history of eosinophilic disease
Middle-aged male predominance
Environmental allergens
Parasitic infections
Drug exposures
Immune system disorders

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Chronic abdominal pain and diarrhoea
  • Unexplained weight loss
  • Detection of peripheral eosinophilia
  • Development of ascites
  • Obstructive symptoms
  • Digestive complaints accompanied by atopy

Treatment Methods

01
Dietary elimination (six-food elimination)
02
Systemic corticosteroids (initial response)
03
Topical/swallowed corticosteroids
04
Mast cell stabilisers (cromolyn)
05
Leukotriene receptor antagonists
06
Biological agents (anti-IL-5)
07
Allergen avoidance
08
Long-term gastroenterology follow-up

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.