Eosinophilic Gastroenteritis

A rare chronic inflammatory disease characterized by eosinophilic infiltration of the stomach and intestine.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Eosinophilic Gastroenteritis?

Eosinophilic gastroenteritis is a rare chronic inflammatory disease characterized by eosinophil infiltration of the wall of the stomach and/or small intestine. It is classified as mucosal, muscular, or serosal type depending on the involved layer of the gut wall.

The mucosal type presents with abdominal pain, diarrhea, and malabsorption; the muscular type mimics obstruction; and the serosal type is marked by eosinophilic ascites. About 50% of patients have atopy or peripheral eosinophilia.

Diagnosis is established by demonstrating prominent eosinophilic infiltration on endoscopic biopsies and excluding other causes (parasitic infection, drug reaction, celiac disease).

Symptoms

Abdominal pain and cramps

Chronic diarrhea and malabsorption

Nausea, vomiting, and loss of appetite

Weight loss

Ascites (in serosal type)

Findings of obstruction (in muscular type)

Peripheral blood eosinophilia

Risk Factors

History of atopy (asthma, rhinitis, eczema)

Food allergies

Family history of atopy or eosinophilic disease

Age 20-50

History of drug allergy

History of parasitic infection

Coexisting eosinophilic esophagitis

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Unexplained chronic abdominal pain and diarrhea
When weight loss is also present
When elevated eosinophil levels are found in the blood
Recurrent attacks of bowel obstruction
If ascites and abdominal swelling develop

Treatment Methods

Systemic corticosteroids (first choice; prednisolone)

Elimination diets (according to food allergens)

Budesonide for maintenance

Montelukast and mast cell stabilizers

Biologic agents in resistant cases (mepolizumab, omalizumab)

Surgical evaluation in obstruction (last resort)

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.