Reinke's Edema

Polypoid degeneration of the vocal folds within Reinke's space

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 17, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our KBB (Kulak Burun Boğaz) department. Book Appointment →

What is Reinke's Edema?

Reinke's edema is a polypoid degeneration of the vocal folds characterized by jelly-like fluid accumulation in the superficial lamina propria, the so-called Reinke's space. Cigarette smoking is the dominant aetiological factor.

Bilateral involvement is typical and the swelling of the vocal folds lowers the fundamental frequency of the voice, often producing a masculine-sounding voice in women. Hypothyroidism and gastro-oesophageal reflux are recognized predisposing conditions.

Treatment relies on smoking cessation, voice therapy and, when warranted, microlaryngoscopic surgical decortication of the polypoid mucosa.

Symptoms

Thickened, husky voice quality

Masculine-sounding voice in women

Chronic hoarseness

Voice fatigue with extended speaking

Shortness of breath in advanced cases

Risk Factors

Cigarette smoking (most important factor)

Hypothyroidism

Gastro-oesophageal reflux

Chronic vocal abuse and overuse

Female sex

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Persistent thickening or lowering of the voice
Progressive hoarseness lasting more than two weeks
Onset of breathlessness or stridor
Voice change in any chronic smoker

Treatment Methods

Mandatory smoking cessation

Voice therapy with a speech-language pathologist

Treatment of coexistent hypothyroidism if present

Anti-reflux therapy and lifestyle measures

Microlaryngoscopic surgical decortication for refractory cases

Postoperative voice rehabilitation

Which Department to Visit?

You can visit our KBB (Kulak Burun Boğaz) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.