Laryngeal Papilloma (Recurrent Respiratory Papillomatosis)

HPV-associated recurrent papillomas of the airway

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 17, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our KBB (Kulak Burun Boğaz) department. Book Appointment →

What is Laryngeal Papilloma (Recurrent Respiratory Papillomatosis)?

Recurrent respiratory papillomatosis is caused by human papillomavirus (HPV) types 6 and 11 and produces recurrent papillomatous lesions throughout the upper and lower airway. The juvenile-onset form follows a more aggressive course than the adult-onset form.

Lesions characteristically arise at the anterior commissure and on the vocal folds and may extend into the trachea and bronchi. Hoarseness is the earliest symptom, while progressive airway obstruction can become life-threatening.

Surgical removal is the cornerstone of treatment, but recurrence is the rule. Adjuvant therapies such as cidofovir, bevacizumab and interferon are used to lengthen disease-free intervals.

Symptoms

Progressive hoarseness

Stridor and dyspnoea

Chronic cough

Weak cry in affected children

Recurrent respiratory infections

Risk Factors

HPV 6 or 11 infection

Vaginal delivery to a mother with genital HPV

First-born status

Low socio-economic conditions

Immunodeficiency

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Progressive hoarseness in a child
Shortness of breath or stridor
Suspected recurrence in a previously treated patient
Voice change persisting beyond two weeks

Treatment Methods

Microlaryngoscopic surgical excision

CO2 laser vaporisation

Intralesional cidofovir injection

Systemic bevacizumab in severe disease

Adjuvant HPV vaccination

Regular endoscopic surveillance

Which Department to Visit?

You can visit our KBB (Kulak Burun Boğaz) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About KBB (Kulak Burun Boğaz) Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.