Ectopic GH-Secreting Tumor

A non-pituitary tumor that produces growth hormone or GHRH and causes acromegaly.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Ectopic GH-Secreting Tumor?

An ectopic GH-secreting tumor is a non-pituitary lesion that secretes growth hormone or growth-hormone releasing hormone GHRH, leading to acromegaly.

It is most often a neuroendocrine tumor of the pancreas or lung.

It accounts for less than 1 percent of acromegaly cases.

Symptoms

Enlargement of the hands, feet and facial features

Coarsening of facial features

Excessive sweating and persistent headaches

Insulin resistance and arthralgias

Symptoms specific to the tumor source such as cough or abdominal pain

Risk Factors

Underlying neuroendocrine tumor

MEN1 syndrome

Carcinoid syndrome

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Acromegaly findings without a pituitary adenoma on MRI
Significant elevation of GHRH on biochemical testing
Symptoms of a primary tumor in the pancreas or lung

Treatment Methods

Localization of the source by 68Ga-DOTATATE PET-CT

Surgical resection of the primary tumor as first line treatment

Long-acting somatostatin analogs such as octreotide and lanreotide

Pegvisomant when the GH receptor pathway is dominant

Multidisciplinary follow-up by endocrinology, oncology and surgery

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.