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Cutaneous Polyarteritis Nodosa

A form limited to necrotizing vasculitis of medium-sized arteries in the dermis.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Cutaneous Polyarteritis Nodosa?

Cutaneous polyarteritis nodosa (cPAN) is a necrotizing vasculitis of medium-sized arteries. Unlike systemic polyarteritis nodosa, clinical findings are limited to skin and subcutaneous tissue. Painful nodules on the legs, livedo reticularis, and superficial ulcers are typical.

The disease has a chronic course with flare and remission periods. Progression to systemic PAN is rare, although mild systemic findings such as joint pains, peripheral neuropathy, and myalgia may accompany.

It can be triggered by streptococcal infection, hepatitis B, and certain drugs. Diagnosis is made clinically and by histopathology; treatment includes topical, systemic, and immunosuppressive options depending on disease severity.

Symptoms

Painful subcutaneous nodules on the legs
Livedo reticularis (purple lacy appearance)
Superficial ulcers and necrosis
Joint pains
Peripheral sensory loss
Muscle pain
Chronic flare-remission cycle

Risk Factors

Streptococcal throat infections
Hepatitis B and C infection
Inflammatory bowel disease
Certain medications
Autoimmune diseases
Female sex

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If recurrent painful nodules occur on the legs
  • If ulcers develop alongside livedo reticularis
  • If there is unexplained limb pain and weakness
  • If fever accompanies the nodules
  • If systemic findings accompanying symptoms emerge

Treatment Methods

01
NSAIDs and low-dose corticosteroids
02
Colchicine and hydroxychloroquine in selected cases
03
Methotrexate and azathioprine
04
Penicillin prophylaxis (if streptococcal trigger)
05
Antiviral therapy in hepatitis B cases
06
Pain management and prevention of secondary infection

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.