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Cutaneous Mastocytosis

A disease characterized by itchy patches and papules due to mast cell accumulation in the skin.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Cutaneous Mastocytosis?

Cutaneous mastocytosis is a heterogeneous group of diseases that occurs when mast cells are present in the skin in greater than normal numbers. The most common form is urticaria pigmentosa.

The lesions are itchy, brown-red macules and papules. Stroking the lesions causes redness and wheal formation in the skin (Darier's sign). Progression to systemic mastocytosis can occur.

It usually has a benign course in children and may regress at puberty; in adults the risk of systemic involvement is higher.

Symptoms

Brown-red macules and papules
Wheal formation when lesions are stroked (Darier's sign)
Intense itching
Sudden flushing attacks
Headache and abdominal pain
Diarrhea and nausea
Anaphylaxis (with certain triggers)

Risk Factors

KIT gene mutation (D816V)
Family history (rare)
Triggers such as alcohol, NSAIDs, opioids
Temperature changes
Insect stings
Radiocontrast agents
Stress and emotional factors

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When brown, itchy patches are observed in a child
  • When new-onset flushing, itching and anaphylactic attacks occur in an adult
  • When abdominal pain, diarrhea, weight loss accompany
  • If there is a history of severe allergy to insect stings
  • If bone pain and osteoporosis develop

Treatment Methods

01
H1 and H2 antihistamines
02
Topical corticosteroids
03
Cromolyn sodium (for gastrointestinal symptoms)
04
Adrenaline auto-injector for anaphylaxis
05
Trigger avoidance and patient education
06
Joint follow-up with hematology in systemic involvement

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.