Cryoglobulinemic Vasculitis

Systemic vasculitis caused by cold-precipitating immunoglobulins.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Cryoglobulinemic Vasculitis?

Cryoglobulinemic vasculitis is a systemic vasculitis triggered by deposition of cold-precipitable immunoglobulins (cryoglobulins) in small and medium vessels. Mixed (type II) and polyclonal (type III) cryoglobulinemias are the most common vasculitic forms.

Hepatitis C virus accounts for 70 to 90 percent of mixed cryoglobulinemia cases; other infections, autoimmune diseases, and lymphoproliferative disorders may also be responsible.

The classic Meltzer triad — palpable purpura, arthralgia, and weakness — is highly suggestive. Renal involvement typically presents as membranoproliferative glomerulonephritis. Treatment focuses on the underlying cause, especially HCV eradication.

Symptoms

Palpable purpura, particularly on the lower extremities

Arthralgia

Raynaud phenomenon

Peripheral neuropathy

Renal involvement — proteinuria and hematuria

Generalized malaise and fatigue

Cutaneous ulcerations

Risk Factors

Hepatitis C virus infection

Hepatitis B virus infection

Sjogren syndrome

Lymphoproliferative disorders

Systemic lupus erythematosus

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Cold-induced skin lesions and joint pain
Onset of palpable purpura with peripheral neuropathy
Decline in renal function in a patient with HCV
Raynaud phenomenon accompanied by systemic complaints

Treatment Methods

Hepatitis C eradication with direct-acting antivirals

Rituximab for severe organ involvement

Corticosteroids during acute vasculitic flares

Plasmapheresis for marked hyperviscosity or organ-threatening disease

Cold-avoidance counseling

Routine renal and neurological surveillance

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.