Conn Syndrome (Primary Aldosteronism)

A cause of resistant hypertension due to excessive aldosterone secretion of adrenal origin.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Conn Syndrome (Primary Aldosteronism)?

Primary aldosteronism (Conn syndrome) is a condition in which the zona glomerulosa of the adrenal cortex autonomously secretes excessive aldosterone despite renin suppression. It is considered the most common treatable cause of secondary hypertension.

It has two main subtypes: unilateral aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia. While adrenalectomy can be curative in the unilateral form, medical treatment with mineralocorticoid receptor antagonists is preferred in the bilateral form.

Plasma aldosterone/renin ratio is used for screening; salt loading or fludrocortisone suppression tests are performed for confirmation.

Symptoms

Resistant hypertension

Muscle weakness and cramps

Polyuria and polydipsia

Fatigue and headache

Palpitations and arrhythmia

Neurologic findings of hypokalemia

Long-term cardiovascular remodeling

Risk Factors

Resistant hypertension (despite ≥3 drugs)

Spontaneous or diuretic-induced hypokalemia

Adrenal incidentaloma

Early-onset (under 40 years) hypertension

Family history of early hypertension or stroke

Concurrent sleep apnea

Familial aldosteronism types

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

In the presence of resistant hypertension
High blood pressure together with hypokalemia
Diagnosis of hypertension at a young age
When adrenal incidentaloma is detected
Spontaneous hypokalemic attacks and hypertension

Treatment Methods

Laparoscopic adrenalectomy in unilateral adenoma

Spironolactone or eplerenone in bilateral hyperplasia

Additional antihypertensives for blood pressure control

Low-salt diet

Monitoring potassium level

Aldosterone/renin and bilateral adrenal venous sampling before surgery

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.