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Chronic Spontaneous Urticaria

Recurrent hives and itching lasting more than 6 weeks with no clear trigger.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Chronic Spontaneous Urticaria?

Chronic spontaneous urticaria (CSU) is a heterogeneous disease in which itchy wheals appearing suddenly and disappearing without a trace within 24 hours, and/or angioedema, persists for more than 6 weeks. In most cases no clear trigger can be found.

In its pathogenesis, excessive release of histamine and other mediators by mast cells plays a key role. In some patients autoimmune mechanisms (autoantibodies against FcεRI and IgE) are involved.

The disease can severely reduce quality of life. Sleep, work, and social life are affected. Today, omalizumab and newer targeted therapies offer effective options for cases resistant to antihistamines.

Symptoms

Recurrent urticarial plaques
Severe itching
Angioedema on lips, around the eyes, or hands
Burning and stinging sensation
Nighttime flares and sleep disturbance
Daytime fatigue
Anxiety and depression accompany

Risk Factors

Autoimmune thyroiditis and other autoimmune diseases
Female gender
Stress and sleep irregularity
Infections
NSAID intolerance
Eating habits and genetic predisposition

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If urticaria lasts more than 6 weeks
  • If angioedema causes shortness of breath in the throat (emergency)
  • If current antihistamines are insufficient
  • If it severely affects daily life and sleep
  • If accompanied by systemic symptoms

Treatment Methods

01
Non-sedating H1 antihistamines (standard 1st line)
02
Increasing the dose up to 4-fold
03
Omalizumab (anti-IgE biologic)
04
Cyclosporine and montelukast options
05
Avoidance of triggers and stress management
06
Chronic disease monitoring and screening for accompanying autoimmune disease

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.