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Chronic Brucellosis

Long-term complicated course after inadequately treated or untreated brucellosis

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Internal Medicine department. Book Appointment →

What is Chronic Brucellosis?

Chronic brucellosis is the form of Brucella infection in which symptoms persist for months or years due to inadequate treatment or relapse, with focal involvement in various organs. It often presents with osteoarticular, cardiovascular, and neurological manifestations.

The most commonly involved sites are the sacroiliac joints and the vertebral column; osteomyelitis, discitis, and paravertebral abscesses may develop. Cardiac involvement may present as bacterial endocarditis, while central nervous system involvement manifests as neurobrucellosis.

Diagnosis is based on clinical history, serology, and culture. Treatment requires prolonged combination antibiotic regimens, with surgical drainage and local intervention indicated in selected cases.

Symptoms

Persistent fatigue and weakness
Undulant fever and night sweats
Sacroiliac and vertebral pain
Myalgia and depressed mood
Joint swelling and restricted motion
Findings of endocarditis or meningitis
Hepatosplenomegaly

Risk Factors

Inadequate or inappropriate treatment of acute brucellosis
Continued consumption of raw milk and fresh cheese
Animal husbandry and veterinary work
Immunosuppressive states
Prolonged exposure to the source
Delayed diagnosis

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Persistent symptoms after acute brucellosis
  • Persistent back, low-back, and hip pain
  • Unexplained fever and weight loss
  • Suspicion of endocarditis or meningitis
  • Recurrent episodes of weakness and sweating

Treatment Methods

01
Prolonged combination antibiotic therapy (8-12 weeks or longer)
02
Doxycycline + rifampin + aminoglycoside protocols
03
Intensive therapy for endocarditis and neurobrucellosis
04
Abscess drainage and surgical intervention when necessary
05
Long-term serological and clinical follow-up
06
Prevention of re-exposure to the source

Which Department to Visit?

You can visit our Enfeksiyon Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Enfeksiyon Hastalıkları Department

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.