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Bullous Pemphigoid

The most common autoimmune blistering disease in the elderly, presenting with tense bullae.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Bullous Pemphigoid?

Bullous pemphigoid is the most common autoimmune blistering skin disease in the elderly. It is characterized by autoantibody formation against hemidesmosomal proteins at the basement membrane zone.

Clinically, itchy, erythematous, urticarial plaques first appear; within weeks, tense, clear-fluid bullae develop on this background. Most often located in flexural areas, trunk and legs.

It has a better course than pemphigus, but mortality is significant in the elderly population; topical and systemic corticosteroids are the main treatment options.

Symptoms

Tense, clear-fluid bullae
Intense itching
Erythematous and urticarial plaques
Localization in flexural and flexor areas
Negative Nikolsky sign
Mild erosions in the mouth (rare)
Association with mental status changes

Risk Factors

Over 70 years of age
Neurological diseases (dementia, Parkinson's, stroke)
Some drugs (gliptins, diuretics, antibiotics)
Genetic predisposition
Psoriasis and some dermatological diseases
Malignancy association (rare)
UV exposure and trauma

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When elderly individuals have severely itchy urticaria-like plaques
  • When tense bullae develop
  • When bullae appear after a medication is started
  • If infection, fever or wound enlargement is present
  • When the existing treatment is not sufficient

Treatment Methods

01
High-potency topical corticosteroid (clobetasol)
02
Systemic corticosteroid (moderate-severe cases)
03
Doxycycline and nicotinamide
04
Azathioprine, mycophenolate mofetil
05
Rituximab (resistant cases)
06
Wound care and infection prevention

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.