Autoimmune Hepatitis

Chronic liver inflammation caused by the immune system attacking the liver.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Autoimmune Hepatitis?

Autoimmune hepatitis is a chronic liver inflammation that develops when the immune system mistakenly attacks liver cells. While it can occur at any age, it is more common in young women. It has two subtypes: Type 1 and Type 2.

Type 1 autoimmune hepatitis is the most common form and is characterized by positive anti-nuclear antibody (ANA) and anti-smooth muscle antibody (ASMA). Type 2 is seen more often in children, with positive anti-liver kidney microsomal antibody (anti-LKM1) being typical.

Untreated, it may progress to fibrosis, cirrhosis, and liver failure. However, immunosuppressive therapy can achieve remission in the majority of patients.

Symptoms

Fatigue and weakness

Pain or discomfort in the right upper abdomen

Jaundice (yellowing of skin and eyes)

Joint pain

Pruritus (itching)

Nausea and loss of appetite

Risk Factors

Female sex

History of other autoimmune diseases (thyroiditis, celiac, etc.)

Family history of autoimmune disease

Certain HLA genotypes (HLA-DR3, HLA-DR4)

Triggering after viral hepatitis

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

If there is unexplained fatigue and jaundice
When liver enzymes are elevated for unknown reasons
If abdominal pain and loss of appetite persist
If signs of flare develop in known autoimmune hepatitis

Treatment Methods

Induction therapy with prednisolone

Maintenance immunosuppression with azathioprine

Mycophenolate mofetil (alternative when azathioprine is not tolerated)

Liver biopsy to assess disease activity

Liver transplant evaluation in treatment-refractory cases

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.