Androgen-Secreting Tumors

Ovarian and adrenal tumors that secrete excess androgens; cause rapidly developing hirsutism and virilization.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Androgen-Secreting Tumors?

Androgen-secreting tumors are rare tumors arising from the ovaries or adrenal glands that secrete excessive amounts of testosterone, DHEA, or DHEAS. They present with rapid-onset hirsutism, virilization, voice deepening, and clitoromegaly in women.

Ovarian tumors include Sertoli–Leydig cell tumors, hilar cell tumors, and ovarian thecomas; adrenal sources include adrenal adenomas and adrenal carcinoma. They must be differentiated from polycystic ovary syndrome and non-classic congenital adrenal hyperplasia.

Serum testosterone >200 ng/dL or very high DHEAS levels suggest an organic cause (a tumor) and warrant advanced imaging.

Symptoms

Rapid-onset hirsutism

Voice deepening

Clitoromegaly

Increased muscle mass and male-pattern body change

Temporal hair recession

Amenorrhea and breast atrophy

Acne and seborrheic skin

Risk Factors

Female sex (peri- and postmenopausal)

Marked androgenic features

History of adrenal or ovarian tumor

Familial endocrine tumor syndromes

Rapid progression unlike PCOS

Virilization developing in pregnancy

Family history of ovarian or adrenal carcinoma

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Rapid-onset hirsutism and virilization
Voice deepening and clitoromegaly
Very high serum testosterone or DHEAS
Peri- or postmenopausal androgenic features
Sudden virilization in pregnancy

Treatment Methods

Surgical removal of the tumor (curative aim)

Oophorectomy for ovarian tumors

Adrenalectomy for adrenal tumors

Chemotherapy and targeted therapy in malignant cases

Postoperative hormonal and metabolic follow-up

Dermatologic support (hirsutism, acne)

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Endokrinoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.