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Goodpasture Syndrome

An autoimmune disease in which lungs and kidneys are simultaneously affected by anti-GBM antibodies.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

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What is Goodpasture Syndrome?

Goodpasture syndrome (anti-GBM disease) is an autoimmune disease in which antibodies against type IV collagen of basement membranes damage both alveoli and glomeruli. Classically, it presents with both alveolar hemorrhage and rapidly progressive glomerulonephritis.

The disease has two peaks: in young men in their 20s-30s (pulmonary-renal form) and in elderly patients in their 60s-70s (isolated renal form). Hemoptysis and rapidly progressive renal failure are typical findings.

Diagnosis is made by demonstrating anti-GBM antibodies in serum and linear immunofluorescence staining on kidney biopsy. Plasmapheresis, immunosuppression, and rapid diagnosis are critical for survival and renal function.

Symptoms

Hemoptysis
Dyspnea
Weakness and pallor
Hematuria
Oliguria
Hypertension
Edema

Risk Factors

Young male or elderly patient
HLA-DRB1*1501 positivity
Smoking
Hydrocarbon exposure
Viral upper respiratory tract infection
Cocaine inhalation
Lithium use

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Hemoptysis with change in urine color
  • Sudden-onset renal failure
  • Unexplained anemia
  • Rapidly worsening respiratory status

Treatment Methods

01
Emergency plasmapheresis
02
High-dose corticosteroid
03
Immunosuppression with cyclophosphamide
04
Hemodialysis (if needed)
05
Smoking cessation
06
Anti-GBM levels for follow-up

Which Department to Visit?

You can visit our Göğüs Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Göğüs Hastalıkları Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.