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Tafamidis: Transthyretin Stabilizer Therapy

A specific TTR-stabilizer therapy that reduces mortality in ATTR cardiac amyloidosis.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kardiyoloji department. Book Appointment →

What is Tafamidis: Transthyretin Stabilizer Therapy?

Tafamidis is an oral drug that stabilizes transthyretin tetramers and prevents their dissociation into monomers and the formation of amyloid fibrils. The ATTR-ACT trial showed reductions in mortality and cardiovascular hospitalization.

It is indicated in both variant (hATTR) and wild-type (ATTRwt) cardiomyopathy. It is effective in NYHA class I–III patients and less effective in advanced disease.

It is given as 61 mg/day (tafamidis meglumine) or 80 mg/day (tafamidis free acid). The safety profile is generally favorable, with mild gastrointestinal symptoms as the most common side effect.

Symptoms

Heart failure
Arrhythmia
Fatigue
Exercise intolerance
Peripheral edema
Neurologic symptoms in hATTR
Gastrointestinal symptoms

Risk Factors

Proven ATTR amyloidosis
NYHA class I–III
Positive PYP scintigraphy
Genetic TTR variant
Advanced age
Male sex
Early diagnosis

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Confirmed ATTR cardiomyopathy
  • Worsening heart failure
  • New arrhythmia
  • Start of therapy
  • Drug intolerance
  • Side effect management

Treatment Methods

01
Tafamidis 61 mg or 80 mg/day
02
Standard heart failure therapy
03
Arrhythmia management
04
Anticoagulation in atrial fibrillation
05
Regular cardiac follow-up
06
Monitoring of side effects
07
Multidisciplinary care

Which Department to Visit?

You can visit our Kardiyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.