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Pulmonary Artery Denervation

An investigational catheter-based therapy that ablates sympathetic fibers in the pulmonary artery adventitia in Group 1 pulmonary hypertension.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kardiyoloji department. Book Appointment →

What is Pulmonary Artery Denervation?

Pulmonary artery denervation (PADN) is a newer percutaneous technique that uses radiofrequency energy to ablate sympathetic nerve endings in the pulmonary artery wall. The goal is to reduce increased sympathetic activity, lower pulmonary vascular resistance and relieve right ventricular afterload.

The procedure is performed during right heart catheterization, with an ablation catheter positioned at the main pulmonary artery bifurcation and main branches. Early studies have reported hemodynamic and functional improvement in patients with Group 1 pulmonary arterial hypertension (PAH) and selected Group 2 patients.

The method remains investigational; it is not a routine guideline-recommended therapy and is used in selected cases within clinical trials.

Symptoms

Progressive dyspnea
Exercise intolerance
Fatigue
Dizziness and syncope
Chest pain
Leg edema
Abdominal distension

Risk Factors

Group 1 pulmonary arterial hypertension
Drug-refractory PH
High pulmonary vascular resistance
Right ventricular dysfunction
Connective tissue disease
Congenital heart disease
Idiopathic PAH

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Deterioration despite optimal drug therapy
  • Worsening dyspnea
  • Syncope
  • Signs of right heart failure
  • Worsening cardiac MRI or right heart catheterization parameters
  • Eligibility for clinical trials

Treatment Methods

01
PAH-specific combination therapy
02
Pulmonary artery denervation in selected cases
03
Diuretic therapy
04
Anticoagulation when appropriate
05
Oxygen therapy
06
Lung transplantation
07
Follow-up at specialized PH centers

Which Department to Visit?

You can visit our Kardiyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.