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IL-6 Inhibitor-Related Myocarditis

Rare myocardial inflammation seen with IL-6 receptor antagonists such as tocilizumab.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kardiyoloji department. Book Appointment →

What is IL-6 Inhibitor-Related Myocarditis?

IL-6 inhibitor-related myocarditis is a rare cardiotoxicity during treatment with IL-6 receptor antagonists such as tocilizumab and sarilumab. Disruption of inflammatory balance may lead to myocardial injury.

Although these agents are used to treat rheumatoid arthritis, cytokine storm and giant cell arteritis, some patients paradoxically develop cardiac inflammation. Elevated troponin, reduced ejection fraction and MRI edema are seen.

Treatment includes discontinuation of the agent, corticosteroids and supportive care. Cardio-rheumatology consultation is important to weigh risk and benefit.

Symptoms

Chest pain
Exertional dyspnea
Palpitations
Weakness
Peripheral edema
Fever and myalgia
Signs of arrhythmia

Risk Factors

High-dose tocilizumab use
Pre-existing cardiomyopathy
Active rheumatoid arthritis
Concurrent infection
Advanced age
Diabetes and hypertension
Obesity

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Chest pain during IL-6 inhibitor therapy
  • New dyspnea
  • Elevated troponin
  • New ECG changes
  • Decline in ejection fraction
  • Syncope or presyncope

Treatment Methods

01
Discontinuation of IL-6 inhibitor
02
Corticosteroid therapy
03
Standard heart failure management
04
Arrhythmia management
05
Supportive care
06
Multidisciplinary follow-up
07
Planning of alternative immunomodulators

Which Department to Visit?

You can visit our Kardiyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.