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Hypoparathyroidism

Low calcium level due to inadequate PTH production by the parathyroid glands.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Internal Medicine department. Book Appointment →

What is Hypoparathyroidism?

Hypoparathyroidism is an endocrine disease characterized by hypocalcemia and hyperphosphatemia due to inadequate parathyroid hormone (PTH) production by the parathyroid glands. The most common cause is damage or removal of the parathyroid glands during thyroid or parathyroid surgery (surgical hypoparathyroidism).

Autoimmune hypoparathyroidism, DiGeorge syndrome (22q11.2 deletion), magnesium deficiency, and post-radiation forms are other causes. Hypocalcemia leads to neuromuscular irritability causing paresthesia, muscle cramps, laryngospasm, and seizures.

Active vitamin D (calcitriol) and calcium replacement form the cornerstone of treatment. Recombinant PTH (teriparatide or natpara) may be used in cases inadequately controlled with conventional therapy.

Symptoms

Paresthesia (around the mouth, fingertips)
Muscle cramps and tetany
Chvostek and Trousseau signs
Seizures
Anxiety and depression
Laryngospasm (in severe cases)

Risk Factors

Thyroid or parathyroid surgery (most common cause)
DiGeorge syndrome
Autoimmune polyglandular syndrome type 1
Magnesium deficiency
Radiotherapy to the neck region

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If perioral numbness and muscle cramps develop after surgery
  • If a seizure occurs
  • If low calcium is detected on blood tests
  • If symptoms cannot be controlled despite treatment

Treatment Methods

01
Acute hypocalcemia: IV calcium gluconate infusion
02
Chronic treatment: calcitriol (active vitamin D) + oral calcium
03
Magnesium replacement (if deficient)
04
Recombinant PTH (in inadequate response to conventional therapy)
05
Goal: keep calcium in the low-normal range (to prevent hypercalciuria)

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.