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Heart Failure with Preserved Ejection Fraction (HFpEF)

A form of heart failure in which left ventricular systolic function is preserved but diastolic function is impaired.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kardiyoloji department. Book Appointment →

What is Heart Failure with Preserved Ejection Fraction (HFpEF)?

Heart failure with preserved ejection fraction (HFpEF) is defined by symptoms of heart failure, impaired diastolic filling and elevated natriuretic peptide levels in the setting of a left ventricular ejection fraction above 50%. The problem lies in relaxation rather than contraction.

Hypertension, diabetes, obesity, aging and atrial fibrillation are central contributors to HFpEF. Left ventricular hypertrophy and atrial enlargement are frequent. HFpEF is more common in women and older adults.

Scoring systems such as the H2FPEF score may support diagnosis. SGLT2 inhibitors are now considered foundational therapy. Diuretics remain important for symptom control.

Symptoms

Exertional dyspnea
Orthopnea
Peripheral edema
Fatigue and exercise intolerance
Atrial fibrillation
Episodes of acute decompensation
Weight gain

Risk Factors

Advanced age
Female sex
Hypertension
Obesity
Diabetes mellitus
Atrial fibrillation
Chronic kidney disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • New-onset dyspnea and edema
  • Rapid weight gain
  • New symptoms in patients with hypertension or diabetes
  • Signs of heart failure

Treatment Methods

01
SGLT2 inhibitors (empagliflozin, dapagliflozin)
02
Diuretic therapy for volume overload
03
Mineralocorticoid receptor antagonists
04
Control of hypertension and diabetes
05
Weight loss and lifestyle modification
06
Management of atrial fibrillation

Which Department to Visit?

You can visit our Kardiyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Related Health Topics

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Hypertension (High Blood Pressure)

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Hypertension is a condition in which blood pressure readings remain above 140/90 mmHg; early treatment helps prevent serious complications.

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Heart Failure

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Heart Attack (Myocardial Infarction)

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A heart attack is a medical emergency; because heart muscle is lost by the minute, immediate intervention saves lives.

Atrial Fibrillation

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Heart Palpitations

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Palpitations are usually due to benign causes, but underlying cardiac rhythm disorders must be ruled out.

Heart Valve Diseases

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Valve stenosis or regurgitation increases the workload of the heart and, over time, can lead to heart failure.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.