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Endocrine Causes of Osteoporosis

Effects of hormonal disorders on bone loss.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Internal Medicine department. Book Appointment →

What is Endocrine Causes of Osteoporosis?

Osteoporosis is a skeletal disease in which bone mass decreases and bone microarchitecture is disrupted, leading to increased fracture risk. While postmenopausal and age-related osteoporosis are the most common forms, endocrine diseases are important secondary causes.

Hyperparathyroidism (cortical bone loss), hyperthyroidism (accelerated bone turnover), Cushing's syndrome (cortisol-induced osteoblast inhibition), hypogonadism (estrogen/testosterone deficiency), GH deficiency and vitamin D deficiency are endocrine causes of osteoporosis.

Secondary causes should be investigated when osteoporosis is detected at a young age or in men. Treating the underlying endocrine disorder can stop or even reverse bone loss.

Symptoms

Usually asymptomatic (until fracture occurs)
Low back and back pain (vertebral compression fracture)
Loss of height and kyphosis
Hip, wrist or vertebral fractures
Fractures from low-energy trauma

Risk Factors

Postmenopausal status
Long-term glucocorticoid use
Hyperparathyroidism and hyperthyroidism
Hypogonadism (early menopause, testosterone deficiency)
Low body mass index
Family history of hip fracture

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If a fracture occurs after low-energy trauma
  • If loss of height is noticed
  • Bone densitometry should be performed when risk factors are present
  • When osteoporosis is detected at a young age or in a man (workup for secondary causes)

Treatment Methods

01
Treating the underlying endocrine disorder (primary approach)
02
Bisphosphonates (alendronate, zoledronic acid)
03
Denosumab (RANKL inhibitor)
04
Teriparatide or abaloparatide (PTH analogs — in severe cases)
05
Calcium and vitamin D supplementation
06
Fall prevention strategies

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.