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Brugada Syndrome

This genetic ion-channel disorder carries a risk of sudden cardiac death in apparently healthy individuals.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

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What is Brugada Syndrome?

Brugada syndrome is a rare genetic disorder caused by mutations in sodium-channel genes (most often SCN5A) that disrupt ion currents in the cardiac cell membrane. The ECG shows a right-bundle-branch-block-like appearance with characteristic ST elevation in leads V1–V2.

In a structurally normal-appearing heart it predisposes to ventricular fibrillation and sudden cardiac death. It is particularly associated with sudden death during sleep in young men of Southeast Asian origin.

Fever, certain medications, and alcohol can unmask the ECG pattern and provoke arrhythmias. After diagnosis, risk stratification and appropriate prophylactic therapy should be planned by an electrophysiologist.

Symptoms

Often produces no symptoms
Fainting or loss of consciousness
Seizure-like movements during sleep
Palpitations
Ventricular fibrillation (may cause sudden death)
Family history of unexplained sudden death

Risk Factors

SCN5A and other ion-channel gene mutations
Male sex (8:1 predominance)
Family history of Brugada syndrome or sudden death
Fever (can unmask the phenotype)
Sodium-channel blockers and certain psychiatric drugs

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • For electrophysiology evaluation when a Brugada pattern is seen on ECG
  • Unexplained fainting or loss of consciousness
  • Genetic screening when there is a family history of early sudden death
  • ECG monitoring and close follow-up during febrile illnesses

Treatment Methods

01
Implantable cardioverter-defibrillator (ICD) in high-risk patients
02
Role of quinidine in suppressing arrhythmias (in selected cases)
03
Early treatment of fever and avoidance of triggering drugs
04
Living with awareness of drugs contraindicated in Brugada syndrome
05
Genetic counseling and screening of family members

Which Department to Visit?

You can visit our Kardiyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.