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Childhood Lymphoma Treatment Protocols

Risk-adapted chemotherapy and radiotherapy protocols are used in Hodgkin and non-Hodgkin lymphomas.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Çocuk Sağlığı ve Hastalıkları department. Book Appointment →

What is Childhood Lymphoma Treatment Protocols?

Pediatric lymphomas account for about 15% of childhood cancers. ABVE-PC and BEACOPP-like protocols are used in Hodgkin lymphoma; international protocols such as BFM and COG-ANHL are used in non-Hodgkin forms.

PET-CT, bone marrow biopsy, and molecular pathology (CD markers, MYC, BCL2) are used for staging. Chemotherapy intensity and radiotherapy use are adjusted by risk group.

Late effects (cardiotoxicity, secondary malignancies, infertility, thyroid dysfunction) require long-term follow-up. The COG Long-Term Follow-Up Guidelines provide systematic surveillance recommendations.

Symptoms

Painless lymph node enlargement
B symptoms (fever, night sweats, weight loss)
Shortness of breath due to mediastinal mass
Abdominal pain and swelling
Bone pain
Pruritus

Risk Factors

Family history of lymphoma
Immunodeficiency (HIV, iatrogenic)
EBV infection
Autoimmune diseases
Post-transplant lymphoproliferative disease
Radiation exposure

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Lymphadenopathy lasting more than a month
  • Unexplained fever and night sweats
  • Significant weight loss
  • Respiratory findings due to mediastinal mass

Treatment Methods

01
Excisional lymph node biopsy
02
PET-CT and bone marrow biopsy
03
Risk-adapted chemotherapy (COG, BFM)
04
Targeted therapy (brentuximab, rituximab)
05
Radiotherapy in selected cases
06
Long-term late-effects surveillance

Which Department to Visit?

You can visit our Çocuk Sağlığı ve Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Çocuk Sağlığı ve Hastalıkları Department

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.